Absence of Netrin-1 would most likely lead to increased what in gut epithelium?

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Multiple Choice

Absence of Netrin-1 would most likely lead to increased what in gut epithelium?

Explanation:
Netrin-1 acts as a survival signal for many epithelial cells, including those in the gut. It binds to receptors such as DCC and UNC5 and activates anti-apoptotic pathways (like PI3K/Akt), helping cells resist programmed cell death as they differentiate and migrate during the rapid turnover of the intestinal lining. Without Netrin-1, this pro-survival signaling is lost, so more gut epithelial cells undergo apoptosis, increasing cell death in the epithelium. Mucus production, nutrient absorption, and differentiation are not directly driven by this survival cue, so they’re not the expected outcome of losing Netrin-1.

Netrin-1 acts as a survival signal for many epithelial cells, including those in the gut. It binds to receptors such as DCC and UNC5 and activates anti-apoptotic pathways (like PI3K/Akt), helping cells resist programmed cell death as they differentiate and migrate during the rapid turnover of the intestinal lining. Without Netrin-1, this pro-survival signaling is lost, so more gut epithelial cells undergo apoptosis, increasing cell death in the epithelium. Mucus production, nutrient absorption, and differentiation are not directly driven by this survival cue, so they’re not the expected outcome of losing Netrin-1.

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